Zero-Mode-Waveguides Used in Cell and Surface Interactions
نویسندگان
چکیده
Zero-mode-waveguides (ZMWs) are subwavelength apertures on metal films. They are fabricated at the CNF with a lift-off process using electron-beam lithography (Figure 1). We further process these structures for biological studies by topping the surface with polyethylene glycol, and selectively coating the inside of the ZMWs with 2,4-dinitrophenyl (DNP) functionalized polymer. Using fluorescence correlation spectroscopy (FCS), we show selective binding of Immunoglobulin G (IgG) to functionalized ZMWs.
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تاریخ انتشار 2008